A degree doesn't make a pilot. If your qualified, and interview well then you will probably get the job. If you have any other life/work/military experience that would demonstrate your ability see something through to completion that also is a positive attribute. In my opinion, I believe a 20 something yr. old would have a harder time without a degree than an older candidate thats 30 yrs. old and over with more experience and maturity. And if the majors are your goal, even though some of the carriers say a degree is not required, it is VERY much prefered. Many majors it is required as well as FEDEX and UPS. I can say I know many pilots flying for regionals that don't have degrees and they are excellent pilots. Final thought, a degree is obviously a great addition to your resume, but if you dont have one, by no means should you feel like your not qualified to fly for a regional. If you have the flight time requirements and feel ready for the training then go for it, you have nothing to lose and you'll most likely succeed. Good luck!