Know of at least one FO and one CA that do that same commute (one might have been Medillin). One had done Columbia to both EWR and to IAH. Both said it was very doable and not that expensive. I always ask about departure taxes in places I've never been but I don't recall it being outrageous. Also know of a few others that commute from various places in Mexico. Consensus seems to be that the only time you may run into trouble is around Christmas time when the flights to/from Latin American are at their fullest. Hopes it helps!