Never heard of anyone having any problems with it whatsoever. Sign up for Global Entry and be done with it. Best $100 you'll ever spend as an international commuter. The guys I mentioned earlier even talked about two-legging it through Mexico and Panama with no problems. More expensive, yes but options. It's all about your planning. As was mentioned before, trying to travel internationally and listing requirements will limit your options somewhat as will international jumpseat agreements (such as American and their stingy international jumpseat rules).