Unfortunately the Major hiring process has changed to your disadvantage...You are competing with thousands of pilots with Part 121 line experience operating in parallel with the respected Major...Networking and Job fairs will help, but your background will move you to one of the "other" resume piles...Don't leave a 110k job for a regional for a chance at a Major Job...That "Commuter" job will most likely sour your taste for work in the airline industry as a pilot...