121 Jet Time is much more valuable than PIC time in a turboprop or a small corporate jet. Sorry, but it is true. There are thousands of regional pilots with a couple thousand PIC 121 time in jets that are applying to the majors. They will get called before someone with PIC in a king air.
Currently, you have almost NO chance of getting hired with a major unless you have 121 jet time (PIC or SIC), or substantial military experience. I recently talked to a check airman that is on the hiring committee at a major, and he said that they would hire a FO at a regional if he had significant experience. His thought was that a major airline FO is going to be an FO for at least 8-10 years. They are going to train that FO to be a Captain the way that they want to. They don't care about how you did it at the regionals, they want you to do it their way.