This is a bit of a tired argument...In the slow times I know there were Lakers that went to other regionals to improve their QOL, but with the current hiring there seems to be no problem moving to a major directly from GLA. I see one to two coming to Spirit a month and one of my FO's from back in the day just went directly Delta. I've already mentioned it but from my class at Lakes those of us who are still in aviation are now at majors (UA, US/AA, SW, AS, NK, F9). Of those I only know of one who went to fly RJ's. Side by side career time frames you'll get PIC time faster and most have a chance to sweeten the resume with check airman, instructor, safety dept, ect... You'll get beat up more and work harder too though. There is plenty of info about that on the boards though.