I thing Typhoon is hitting on the scariest scenario of all for legacy European and N American carriers. Emirates (who Typhoon works for) opening up a northern european hub, with EU access rights, and connecting European passengers to N America. If NAI gets approval, I don't see anything stopping this from happening nearly instantly.
Delta and United can't get 1500 hour pilots? How about a joint venture with their alliance partners' in Europe flying the Atlantic. Both Air France and Luftansa are fighting vigorously with their unions, and would love to stick it to their own employees.
The only constant, is change. Evolve, or perish.