Go where you don't have to commute to work.
TSA crew bases are ORD, IAD, STL and DEN (soon, if not opened yet) and PSA crew bases are TYS, DAY and CLT. What's the cost of living? If you don't want to relocate, how is the commute?
I've flown the CRJs and the EMB-145. My preference is the CRJ. That's probably due to substantially more experience on the CRJs. Good luck!