Neither alpa nor not-alpa will solve the regional problem. Remember there is only a "regional problem" in the eyes of regional pilots...from the perspective of managers (and a lot of mainline pilots) the regional systems works great!

The only solution is vertical or horizontal unity...

Vertical: Regional pilots on mainline list for the brand they fly. This is up to the mainline pilots, and is possible, though doubtless an uphill battle.

Horizontal: One union actually controlling all regional labor (not happening, even the majors don't have this). The west coast longshoreman are the only good example I can think of.