At one time, yes. But a combination of things has changed my mind.

-Uncertainty of the future of regionals. In fact, I'm certain they will be gone with one or two exceptions.
-Better new-hire pay at the majors.
-Quicker pay parity, you can reach it now in year 2 or three.
-Retirement, even with only a few years at the majors retirement will be better funded.

Starting over with vaca and seniority is painful, especially with a family, but in the long run it's worth it.