I'm 58 and am at my third regional and fourth airline overall.
I started as a flight attendant, went to Comair and was there 15 years as a pilot until Delta shut us down. Went to TransStates and commuted the entire time. Commuting in my 30's as a flight attendant was bad...commuting in my 50s, as a pilot, was just as bad if not worse.
An opportunity to go to PSA came along and now I'm DAY based and life is much easier.
Bedrock's response is great and I'll add this...don't commute unless you have too. If one has to commute, commuting to a base where you can also drive is the next best thing. I find working out 5-6 days a week is a huge help.
Doing 3-5 legs a day as a pilot is much easier than 3-5 legs a day as a flight attendant.