I was living in Kansas City (on the Kansas Side) and was based out of St. Louis. Ended up driving numerous times, but more often than not i'd fly. If the flights looked even remotely full, I'd just gas up the car and drive across state.
I lived about 30 minutes from the airport, and would arrive 30-45 minutes prior to boarding for my commute. The flight was right around an hour, then I'd have to trek from the East Terminal to the main terminal for work which could take 20 minutes depending on the metrolink situation, or hopping on the shuttle. After all was said and done, it was about 2.5 hours of "commute" time before I'd arrive at the crew room...when I drove it, I'd be there in about 3.5 hours. Not a WHOLE lot of difference.