Delta has direct mainline from ILM to ATL, some to MYR too.
Don't even think about CHS though. With the AF reserve units there I'm told it's a terrible commute, and we are hiring lots of pilots from there as well.
I think there are regionals operating out of New Bern.
We spent almost 3 years looking for a deep water lot on the SE Atlantic coast. Commuting was a very big factor. We bought in Beaufort SC. SAV isn't a bad commute, and it's not too onerous a drive to ATL if all else fails.
I told my wife I'll commute to work if I can walk to the boat!