I'm a new(er) guy and I have been commuting for going on three years. Before our contract negotiations got ugly, I was able to move and drop my Reserve days pretty easily. Some days (Sunday/Monday) are tough commutes on a FedEx plane. There are limited flights from my area (central Texas) and offline is two legs often on RJs (limited seating). So, I would move my days to avoid tough commuting days. I don't know how far you live from the options you listed but an hour drive or so to a FedEx Jumpseat is not bad. That's basically what I do. Your big city options usually have multiple flights which make it both easier and harder as more FedEx pilots live there.
Commuting is doable and I just accept that my month is a little longer than local guys. It is a choice we've made as we don't want to live in Memphis.