Took 2:40 to get from O'side to the CPO two trips ago. Sunday night red eye. Sunset along I-5 (it's more west than I thought it was) had traffic slow moving from Pendleton through San Juan Capistrano. D Lot parking shuttle bus was stuck in traffic for a long time due to airport terminal gridlock. Started flight planning on the bus because there simply wasn't enough time to do so in the CPO. I gave myself 3 hours door to door.
Found a place in South Bay this weekend. After a late night post 4 day trip drive home to O'side last week, I threw in the towel.
It's doable, just not for me. I know a 737 FO who commutes from Coronado.
The farthest south I'd recommend living is San Clemente.