Boilerup is right - a pilot from Gojets probably will get hired at most if not all majors at some point for many reasons. Some airlines don't use pilots in their interview process. Many major airline pilots don't pay attention to regional issues and don't have a clue about this. Some people have amazing connections.

But as more of the current regional folks move up to the majors, it becomes a much bigger risk. Rather than one bullet in the game of Russian roulette, there are two, and it will keep growing until 5 of the 6 chambers are loaded. I doubt anyone who was a regional pilot while Gojets is/was an issue will forget what happened. For example, look at the Eastern/CAL situation - nearly 20 years have passed and people still talk about it. I know all about it and I was 14! Last month I met gentleman in his 70s who had retired from American, and I though he was having a heart attack when someone mentioned Eastern scabs because he turned this lovely shade of reddish purple.

If you only want to think short term, I'll repeat my first comment: Commuting will be hell because more often then not you'll either get denied the jumpseat or will be 'educated' while you are in the jumpseat. And being in the terminals won't be a picnic either I am sure.