Originally Posted by
PerfInit
It could take as much as 50-100 hours to get back in the groove. 121 consolidation time (100 hrs in 120 days) is there for a good reason...
What equipment will you be on?
Enjoy the experience, and don't be too hard on yourself the first few months back on line...

What he said. In my experience it does come back very rapidly, but immediately out of the gate is rough. Things we take for granted (like hearing your callsign in the radio garble) tend to be rusty and that can catch you off guard.
SIM is relatively easy (scripted vice real-world challenges) so best to warm up in a sim if possible.
If you're jumping into resource-limited (ie airline) training cold-turkey, best to get some kind of warm up first so you don't wind up with a PRIA event.