Honestly I work for Piedmont and I've been called a Cheerleader to get people there. If you can live in base and the upgrade isn't too long I'd say GO to that airline!! Commuting for a Regional Airline can be hell!! While Piedmont does give you 4 hotels a month it still doesn't outweigh the time you can have with your family.
Now if you are single and commuting that's much different then having a family and commuting. I'm not sure of your situation but with a family it's a no brainer. Don't Commute for a regional.