Like the above poster said, it all depends on your life goals, where you live etc...it's hard to say which one is the best, all the regionals suck and generally offer around the same starting pay. Obviously do your research but it's not so much of a difference you'll get rich at any one of them. Not having to commute will make a world of difference when it comes to QOL
My biggest advice is to go to one that has the best commute or no commute. Don't spend your money at job fairs until you're ready for the majors...some of the regionals are so desperate they are doing just phone interviews. If you have a pulse, have the hours, you will get hired somewhere-period.
If upgrading is your top priority that's a whole different topic-just do your research and realize that aspect constantly changes