If you have a desk job somewhere during your last 2-3 years of service, then a regional may be a good option for currency and recency of experience.

I interviewed with two AF retirees in July 14. Both were hired. One was a C-17 IP and the other a F/E, but I don't remember which airframe. Both wanted the 121 experience and the F/E needed the turbine time. I don't expect either of them to be at PSA too long.