It just depends on what your goals are really. Sure it is true that majors have been hiring FOs from regionals at an increasing rate. However if you look at the statistics for those hired over the past year at any of the 3 legacies, you will see that the overwhelming majority of them had TPIC. It isn't the golden ticket some claim it to be, but it does help to check one more box, and make you some more money at the same time.
The fact is, whether you want to go to a legacy, LCC, ULCC, or whatever from a regional, TPIC is going to make you a more attractive candidate.