Depends where in PIT you're at, 3:20-4 hours. Obviously, easier if you live right near an exit. I think my record was 3:25 nonstop. If I'm remembering this right, get off at Harrisburg East to go to MDT (first exit after you cross Susquehanna). Could get brutal during the winter when it was snowy near Somerset. Guy in my crashpad lived up by New Castle and did the trip via I-80/81 and it wasn't any longer than the turnpike.

Also depending on where you live, DTW employee lot is also just about a 4 hour drive. Did that drive many times, too. PA/OH turnpike tolls to DTW were actually cheaper than going to MDT.

The drive is a great option: Never gotten bumped due to weight or loads out of my own car.