Although I personally didn't fly any single-engine military aircraft, I've have flown with many ex-F-16 guys at AA. I also know back in the day United applied a multiplier to fighter time, including F-16s, so no penalty there. T-6's are instructor time, which is respected and valued. And most pilots who know anything about U-2's know that it is a very demanding aircraft to fly and land, and that only select guys get to fly them. Hence no penalty there either I'm sure...
On the subject of U-2s, I wonder what you find so appealing about pre-breathing 100% oxygen for an hour and having others dress you from your underwear up to space-suit before every mission, then cruise for multi-hour missions without being able to get of the seat and a rapid D from 60K ft + is a real ugly emergency then back to a landing that can be a real crap shoot

??? Hey, to each his own...I highly respect them but wouldn't want to do it.
What do you fly in the AF now? I'd say go with a heavy (I did C-130, C-141, C-17)...lots of hours and a much better lifestyle!