If this is important to you, you must live in domicile. It's also dependent upon the domicile as well. DEN and MSP at SkyWest have a lot of 4 day trips, however bid at the 50% or better level in SLC and you might only spend a night or two a week in a hotel. At that level it's entirely possible to fly locals or 2-3 day trips. I bid between 40-50% (so I'm not really all that senior) in SLC and used my overnight bag last year for less than a dozen nights. In fairness though, bidding 20% in other domiciles may have seen you doing 3-4 day trips still.

The pilots at SkyWest also get 5 guaranteed days off a year (Gold Days). They cant be used over holidays, but you can use them for birthdays, anniversaries, etc..

Frankly though, this career requires a good deal amount of time away from home. If you don't have a spouse that can handle that find another job.

Every time you take an upgrade or move on to a better company it requires going back to a crummy schedule, something else to think about. It's probably the biggest reason why the top 20% of the seniority list is going anywhere here.

I need to add that even though I didn't use my overnight bag all that much, I still worked a lot of weekends. If you think you'll have weekends off like normal people - forget about it. That will require seniority in domicile and working 4 day trips during the week.