No one is saying don't take the job. But most of us 'old timers' would have apps out while working on our CFI or trying to find another time building job because it's the practical thing to do. Why are you worrying about how to get to your next regional before you've been to your first? Not everyone will get to FDX, UPS, or SWA. Just like not everyone will get to SKW, XJT, or RAH (pick your flavor of the month). Seriously man, you have 400 hours...it's good to think ahead but the next challenge, getting the first airline job, is a much higher threat to be focused on right now.