Based at home or a base you are willing to move for should without question be number 1. There is no larger influence on QOL, and as a side benefit the ability for more pay, as you can be highly flexible. Then if you are based at home, reserve time doesn't really matter either because living in base on reserve can be highly desirable. As you can get paid to sit home or play golf and not work on many reserve days, then if you want you can fly OT on your off days. It's Win Win. Least amount of flight hours for the most amount of money. Airline piloting 101.