It will be at least a decade before any of this even starts to come to fruition, but it will only be after the widespread adoption of driverless cars. Once the general public begins to see full automation in their everyday lives and become comfortable with it, then we'll start to see it gradually come into aviation.... I think it will take a decade before driverless cars become "the norm" and even longer for it to go into aviation.
After that we'll see a big attitude shift on this...
First thing will likely be moving cargo operations down to 1 pilot. And then eventually passenger aircraft. After that cargo will go fully automated. I don't think passenger aircraft ever will though, or at least not for 50+ years until the technology is without a doubt rock solid. And even then, it will be highly political with unions and Congress and such (which is why I think it will be at least 50+ years before passenger aircraft are fully automated, if at all).
Just my opinion, mileage may vary.