It's been slightly eluded to in the responses but the one thing you really need to consider is once you leave the US and get this "dream" job what is your plan? Are you doing this with the intent to come back to the US at some point with all of your marketable skills? If so, what is your exit strategy? Leaving some of these places is a royal pain in the ***. If you plan on staying you need to seriously consider what your quality of life is really going to be like and by no means take a job without spending a little bit of time in the city or country you would be living. Finally, if your wife and family aren't completely on board it should be a "no go" item IMO.