Originally Posted by
stringandrudder
A lot of people have told me, and I've heard, that the regional you choose DOES matter in terms of landing a job at a major.
No, your chances of being hired at any given major airline do not at all rest on which regional airline you fly for.
There are a lot of things to consider when choosing -- and many of them have been brought up in this thread -- but your question should not be one of the factors, because it just does not matter to the majors when deciding who to call for interviews.