The problem with answering this question is that everyone's situation is going to be different.

There are too many variables (city pairs, location of base, family situation, etc) to really be able to gauge what your experience will be like based on someone else's.

I had a 1-leg commute from a medium-sized city to my base in a large city. There were enough flights that I never had a problem getting to work or home (although I had many commutes in the night before or commutes home the morning after my reserve period).

My wife and kids were used to me being gone a lot from my time in the military. I used the time sitting reserve to be out exploring the city I was based in and doing recreational activities. I found a convenient crashpad, and the base was close enough to where I lived (300 miles) that I drove my car out and left it at my base.

Although I certainly wouldn't want to do it forever, I tried to enjoy the time I spent on reserve at a regional.