As someone said earlier, it's a tough question to answer because everyone's situation is different and there are so many variables that come into play (your airline, seniority, trip selections, home airport, base airport, number of flights, length of flight, fellow commuters, etc.)
Though the general consensus and obvious answer is avoid commuting if possible, everyone's experience will be different. I for one never have to go a night early or stay a night after my trips. I typically don't have to wait very long for a fight either. This has made my commute fairly simple and somewhat painless.
If you do end up commuting just have in the back of your mind that there is always a chance you won't make it home that night after your trip.