I did ACMI for 15 yrs and then made the switch to a major. For QOL you cannot beat a major. It is unbelievable how different it is to have control over your schedule and be able to move trips around and not be gone so much at a time.
The flip side is the trips aren't as much fun and either are the crews and generally they aren't as good as pilots.
But for money and QOL for me it's been with a major.