Where do you live or want to live? I think that's the biggest question here. I know it's a dead horse, but not commuting and living where you WANT to live is the biggest quality of life improvement anyone will ever get.

In the end the novelty of a particular airline and aircraft WILL wear off. Choose the airline that will have you home the most for a given amount of pay. You'll never regret choosing your family over an additional $500k in your 401k.