It all depends on whether the 2 years affects your retirement in any major way (assuming that you are in that category). I think regional airlines would hire you without issue and the 121 time would eventually make you competitive for a legacy carrier. However, I think you should stay a bit longer to get that IP box checked. Yes, a lot can change in two years, and seniority is key in the airline business. Depending on your age, get the IP and consider a wholly owned regional (AA, UAL, DL) depending on your preference. If you don't want to interview again or don't have a degree, Envoy, PSA or PDT are the best options right now.