I left that cargo operator in CVG for United. I sat reserve for only two months before holding a line in EWR. My quality of life has increased by orders of magnitude. I've had as many as 17 days off as a lineholder. In addition, my first year pay at UA beats my fifth year pay hauling yellow boxes. Between aggressive pick up as a reserve and trip trading as a lineholder, you should be able to get commuteable trips most of the time.
Two caveats: First, I live in Mass, not CVG, so I was not at home on my CVG overnights. And I now (mostly) drive to EWR. A drive, even a four hour drive, is not the same as commuting on an RJ. Second, depending on when you hit the line, you may well sit reserve for a much longer period than I did. But I would be surprised if it were as much as a year in EWR.