My two cents: Come to UAL. I worked for a large 747 cargo carrier before UAL. Roughly 2 weeks on, 2 off. Great schedule for me. I hemmed and hawed over UAL precisely because I didn't like commuting 3 or 4 times per month like I did at the regional. Now at UAL I can wrangle PBS to give me roughly the two week on, two week off schedule using 30 hour layover trips, 3+4 day trips back to back depending on show/quit, etc. I can't recall a month where I had fewer than 10 days off in a row. With a 17 day off line I've had up to 15 off in a row. That's just a normal line at 50% to 70% seniority on the SFO 320 FO. With PBS I have more control over which days off I get and where they're allocated. Reserve is tougher to schedule but you can still get an 8 day off block pretty reliably. Commuting to reserve totally sucks, as usual.