My commuting experience has been OK...

1st commute: Transcon, 3x daily nonstops on mainline airbuses (2 jumpseats). I'd only come home if I had 3-4 days off, but this was a temporary arrangement until I could bid back to the other side. The flight itself was grueling, but it was one leg and there was not a lot of stress as to whether I would get to work (6 daily jumpseats).

All my other commutes have been one leg, less than 3 hours, plenty of daily company and mainline iron, plus SWA or other carrier non-stops. I bid afternoon shows, get up for the early flight, then find stuff to do in domicile for a few hours. I have a car, crash pad, and recreational gear. Conveniently there is a late flight home every day, and I almost always return in time to catch it, so I rarely overnight or commute on my days off.

Commuting is not too bad if you have:

Less than 3-4 hour flight.

Multiple daily non-stops on company or mainline.

Another carrier with backup flights (hopefully non-stop).

Can bid late shows so you can come in the same day.

Can bid 4+ day trips so you get per diem and a hotel the whole time.

Also the number of other commuting pilots who are senior to you or have priority (mainline) is a factor, but this is hard to determine except by trial and error.