Lock your memories of flying the airplane deep in your minds. The largest challenge will be the automation and descent planning. Secondary, get prepared to move or commute, for the rest of your 121 career, airlines are always closing and opening domiciles, and even chaining the doors shut. The only certainty is the continued uncertainty. If your relationship isn't titanium/rock solid, shop for a good divorce attorney, you will give/promise them lots of money. In 20+ years in the 121 biz, I have watched starry eyed f/os, come to work and over time watch the dissolution of long term relationships. Myself included, this job cost me a long term relationship and at short count, about 500k in lost real estate potential gains, due to having to sell jointly owned real estate in the SF South Bay Area, today those properties would have been worth several million. She couldn't deal with the me being gone for 4+ days at a time.