Honestly, the biggest aspect to consider commuting out of LAS is that it is going to be hard to get *to* Vegas on a Friday night, and hard to leave Vegas on a Sunday evening or Monday morning.

I commuted to LAX for a year, which is possibly the easiest flying commute known to mankind: 30-ish flights per day, each way, on numerous different airlines. Still, the friday-sunday-monday rule of thumb made commuting during those times challenging, and I often had to go to work the night before and get a hotel, or get a hotel and go home the morning after a trip.

Some junior regional domiciles are tough from LAS, as smaller towns aren't likely to have direct flights (many of the east coast regional junior bases, for example), but most of the big cities are going to have at least something useful.