It's always worth applying because the worst that will happen is you never get called by them. But with 250/50 don't expect to get called anytime soon. Yeah, they were hiring with those times in the very very recent past but they currently aren't. I had a friend with hours slightly higher than yours get her resume walked in about a month ago and she didn't get called. Apparently with lowering their upgrade minimums they've been flooded with resumes with people who have higher time and jet experience. They're probably hanging on to low time resumes for a few months until they get desperate again.