Others have said it. There is no one right answer for everyone. Having a family or not makes a huge difference. Liking where you live or looking for a change. In my case I'm fortunate to live near two major airports that have lots of airlines to choose from. I'll go to one of those airlines and leave my family where it is. If/when I go to a major airline, we will look at potentially moving the family then, but that is a long way out. For now, we are counting on me being eventually able to hold a base right by our home and not having to deal with a commute.