Monday night/ tuesday morning(or first night) is brutal...after that you can handle it pretty well. The worst part of it is the last hour of the morning flight to your destination. If you live in base, recovery is pretty easy as you will be done by midnight (ish). If you commute, then you better have an understanding spouse that realizes you need sleep when you get home. Typically, it's a week on week off schedule, and having a week off in between commutes is what makes it worth it for people who bid those lines. Keep in perspective that the "good" at FedEx is time off/vacation...and it is needed. If the pay/benefits/retirement/vacation/schedule flexibility wasn't as good as it is, it'd be hard to fill seats at this place. It's a great place to work because we've been able to hammer out pretty decent contracts (my opinion, only) from the underappreciated union volunteers...enforcing it, however...
Typical pay hours are usually 70-75 8 months of the year, 85-95 4 months of the year. Most of all this has been repeated many times in various posts with varying opinions as well. This is one viewpoint from an average line guy(less than 15 years at the company, junior wide body CA)...