The big question wrt "Career V1" is an inexact, philosophical one. The 2 main groups seem to fall into 2 categories: 1) Those who have a "brass ring" type of position, but not their first choice. 2) Potential "Captain/Lifestyle Lifers" at a regional, ULCC, or ACMI outfit, 50 something.
No dog in the hunt for me, but this thread relevant to Category 1. Offhand, I'd say that if you have 2 or more years with company, and are above the bottom 10% seniority, you'd be better off sticking around, unless there are strong domicile preference issues. Even then, still a bit of a crap shoot.