It's all how you approach it. It means more days away from home. It's tough when you end up commuting off line on 50 seat RJs when you started out with commuting on your own air line.
I take it one commute and one leg at a time and don't try to cut it to the nub and it's not so bad.
That said, if you don't have to commute it's better to live in base. I would never commute to chase a particular seat or aircraft. I commute because I love where I am. I try not to stress about it and I don't push the limits. That can age you.
I will be happy when I can retire and not do it any more.