One issue I have is the inability to bring healthy food. I commute offline on AA and three bags -rollerboard, computer bag, and lunch box - gets the stink eye and I'm told to consolidate. I'm a writer on the side so I need the computer every other week. Since my rollerboard is taken nearly 95% of the time (even on an A321) I have to decide: computer bag or healthy food (not putting the computer in my rollerboard and checking it). The lunchbox gets left behind most times. On my own carrier I could bag drag like a Sherpa, no problem. On AA? Not a chance.
My health concern is commuting home after a redeye. Seattle to JFK. Cab to LGA. Flight to DFW. Uber home 12 miles. Total time of sustained wakefulness each time: roughly 27-30 hours.
Age is 47.