I have close to 5000 hours, almost all of it turbine ME 121 time. But I have less than 200 total PIC. Now that I have upgraded, that will increase rapidly. But my SIC time and all the quality of my time means NIL, NADA, NOTHING, etc.
I get talked to like an equal in terms of experience by whomever I talk to, but when it comes to that all important resumé, there is nothing like PIC and even more nothing like turbine, 121 PIC.
Get thee to a job where you can upgrade quickly.
I see pilots with equal total time (or less) moving on because they got their PIC.
FWIW, I missed out because of a furlough in 2003. Started all over again.
Get your PIC at a regional (preferably jet, but that doesn't play a huge role AFAIK).