Honestly, with your background most likely all you're going to need is to be instrument current (either IPC or have required # of approaches in the past 6 months) for one of the more selective regionals. There will be some that might hire you with the 10 year gap and roll the dice and bank on your background for your ability to complete training.

If you want to go to a 121 major my recommendation would be to to a 121 regional and apply to the majors as soon as you have 100-200 hours at the regional under your belt (100-200 hours in the last 12 months is the benchmark for currency/recency for folks).

I personally recommend folks look at AAs wholly owned regionals so they have a flow creating movement in their seniority list when AA is holding classes, But pick a regional that works for your career goals and where you want to live.