As you said, number one is getting hired. Generally I would suggest saying yes to your first major. And, nothing beats living in your domicile. That being said, FedEx is very commuter friendly because of our pax deadheads to position for many trips. One of our major commuter protections of jumpseating to Memphis and being protected from discipline if the FedEx Jumpseat crumps, has some restrictions. One of those restrictions is the notional length of day from beginning the Jumpseat to when your revenue flight is complete. Most west coast Jumpseats to Memphis combined with the "turn" to the revenue flight don't qualify for the contractual protections, though. But, many, many pilots do commute.
But, I think the best thing I can say about commuting at FedEx is our system form makes it so the vast majority of pilots find something that works for them and makes them happy. With your 10 year look out, I would say with confidence you would find something that would make you very happy with your schedule. That's assuming you are willing to bid seat and aircraft that work for you. I can't tell you what combination of seat and plane would do that for you, but I'm certain that over that timeline you would get something that works well.
Los Angeles is a west coast MD-11 domicile but its very, very senior. Who knows if Anchorage will still be a domicile either--depends on the MD-11 retirement rate in your timeline.
Think about Delta and Seattle. You'll have a fair number of drives each month as that's their system form.
Good luck!