The scheduling program used by an airline is one thing, but who the regional is doing the flying for is more the answer you are looking for. Unless the regional is doing branded flying, the hours are dictated by the mother-ship: Delta, United, American, etc. From talking to others I know one thing, Delta schedules are not great at all. That is why your Skywest friend has only 13 days off and a hard time moving trips. Ask any Comair or CHQ pilot flying DL trips and you'll find they aren't as good schedulewise.
Anyone care to confirm that?