I agree with most the posters...go with the airline that affords you the opportunity to live in base.
After commuting for several years early in my career (when you are needed home the most with small kids) it takes a HUGE toll on your QOL and relationships. If you don't believe me...do the math.
Start the clock the minute you leave the driveway of your home and stop the clock the minute you start getting paid. Do that for both going to/from work, add up the time and project that over a career. I get the fact people LOVE living where the live, but if you have a choice between two airlines and one has a base where you live....no brainer, unless your family is willing to move to one of the other airlines base! Then the decision becomes MUCH more difficult and many other variables probably need to come into play.
Good luck and congrats on having a decision like this!